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Báo cáo khoa học: "he Effect of Transdermal Delivery of Fentanyl on Activity in Growing Pigs"

Tuyển tập các báo cáo nghiên cứu về bệnh thú y được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The Effect of Transdermal Delivery of Fentanyl on Activity in Growing Pigs. | Acta vet. scand. 2005 46 149-157. The Effect of Transdermal Delivery of Fentanyl on Activity in Growing Pigs By L. M. Malavasi H. Augustsson M. Jensen-Waern G. Nyman Department of Clinical Sciences Faculty of Veterinary Medicine and Animal Science Swedish University of Agricultural Sciences Uppsala Sweden. Malavasi LM Augustsson H Jensen-Waern M Nyman G The effect of transder-mal delivery of fentanyl on activity in growing pigs. Acta vet. scand. 2005 46 149157. - Recently decreased activity levels have been observed in pigs treated postopera-tively with transdermal delivery of fentanyl TD-fentanyl after isoflurane anaesthesia. Whether the change in behaviour is related to opioid-induced sedation or to insufficient pain relief remains to be investigated. This study was therefore undertaken to evaluate the effect of TD-fentanyl 50 pg h-1 on the activity level with and without isoflurane anaesthesia. Eight pigs 25.4 5.2 kg were submitted to a cross-over study and given two treatments 1 fentanyl patch applied after 30 minutes of anaesthesia treatment A F and 2 fentanyl patch without anaesthesia treatment F . The pigs behaviour was observed from a video recording instantaneously every 10 minutes for 24 h before treatments and up to 72 h after the patch attachment. Venous blood samples were taken 1 6 12 24 48 and 72 h after the patch application. The behaviour recordings showed that TD-fentanyl did not produce sedation in any pig. No differences were found between the two treatments in activity level weight gain or serum fentanyl concentration. This concentration measured after 24 h was 0.27 0.11 ng ml-1 and 0.47 0.40 ng ml-1 in the A F and F group respectively. In conclusion transdermal delivery of 50 pg h-1 fentanyl did not cause inactivity in growing pigs. However the large variations in serum fentanyl concentration indicate that drug absorption from transdermal patches is unpredictable and sometimes deficient. swine analgesia opioids patch behaviour pain sedation .