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Báo cáo y học: " Differences in susceptibility to German cockroach frass and its associated proteases in induced allergic inflammation in mice"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Differences in susceptibility to German cockroach frass and its associated proteases in induced allergic inflammation in mice. | Respiratory Research BioMed Central Research Differences in susceptibility to German cockroach frass and its associated proteases in induced allergic inflammation in mice Kristen Page 1 3 Kristin M Lierl1 Nancy Herman2 and Marsha Wills-Karp2 3 Address 1Division of Critical Care Medicine Cincinnati Children s Hospital Medical Center Cincinnati OH USA 2Division of Immunobiology Cincinnati Children s Hospital Medical Center Cincinnati OH USA and 3Department of Pediatrics University of Cincinnati Cincinnati Ohio USA Email Kristen Page - kristen.page@cchmc.org Kristin M Lierl - kristin.lier@gmail.com Nancy Herman - nancyherm@yahoo.com Marsha Wills-Karp - marsha.wills-karp@cchmc.org Corresponding author Open Access Published 8 December 2007 Received 4 October 2007 Respiratory Research 2007 8 91 doi 10.1186 1465-9921 -8-91 Accepted 8 December 2007 This article is available from http respiratory-research.cOm content 8 1 91 2007 Page et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Cockroach exposure is a major risk factor for the development of asthma. Inhalation of fecal remnants frass is the likely sensitizing agent however isolated frass has not been tested for its ability to induce experimental asthma in mice. Methods Mice Balb c or C57Bl 6 were sensitized and challenged with GC frass or GC frass devoid of proteases and measurements of airway inflammation and hyperresponsiveness were performed interleukin IL -5 -13 and interferon gamma IFNy levels in bronchoalveolar lavage fluid serum IgE levels airway hyperresponsiveness cellular infiltration and mucin production . Results Sensitization and challenge of .