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Báo cáo y học: "Association of acid phosphatase locus 1*C allele with the risk of"

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Association of acid phosphatase locus 1*C allele with the risk of . | Teruel et al. Arthritis Research Therapy 2011 13 R116 http arthritis-research.eom content 13 4 R116 RESEARCH ARTICLE Open Access Association of acid phosphatase locus 1 C allele with the risk of cardiovascular events in rheumatoid arthritis patients 1 1 2 3 4 María Teruel Jose-Ezequiel Martin Carlos Gonzalez-Juanatey Raquel Lopez-Mejias Jose A Miranda-Filloy Ricardo Blanco 3 Alejandro Balsa5 Dora Pascual-Salcedo5 Luis Rodriguez-Rodriguez6 Roni3min Rorto óírìAci di 11 14Z21KKK ì C ìt i ỉ 77 lo 7 A l 3rr i7 Pi Kt Yicif i CíórnQ7- of ii Idroi8 Ml in 7Ím Rmỳỳifli9 Benjamin Fernandez Gutieiiez Ana M Oitiz Isidoio Gonzalez Alvaio Caimen Gumez Vaqueio Nunzio Bottini Javier Llorca10 Miguel A Gonzalez-Gay33 and Javier Martin13 Abstract Introduction Acid phosphatase locus 1 ACPI encodes a low molecular weight phosphotyrosine phosphatase implicated in a number of different biological functions in the cell. The aim of this study was to determine the contribution of ACPI polymorphisms to susceptibility to rheumatoid arthritis RA as well as the potential contribution of these polymorphisms to the increased risk of cardiovascular disease CV observed in RA patients. Methods A set of 1 603 Spanish RA patients and 1 877 healthy controls were included in the study. Information related to the presence absence of CV events was obtained from 1 284 of these participants. All individuals were genotyped for four ACPI single-nucleotide polymorphisms SNPs rs10167992 rs11553742 rs7576247 and rs3828329 using a predesigned TaqMan SNP genotyping assay. Classical ACP1 alleles A B and C were imputed with SNP data. Results No association between ACPI gene polymorphisms and susceptibility to RA was observed. However when RA patients were stratified according to the presence or absence of CV events an association between rs11553742 T and CV events was found P 0.012 odds ratio OR 2.62 1.24 to 5.53 . Likewise the ACP1 C allele showed evidence of association with CV events in patients with RA P 0.024 OR

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