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Báo cáo khoa học: "Significance of lipopolysaccharide-binding protein (an acute phase protein) in monitoring critically ill patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Significance of lipopolysaccharide-binding protein (an acute phase protein) in monitoring critically ill patients. | Critical Care December 2003 Vol 7 No 6 Prucha et al. Research Open Access Significance of lipopolysaccharide-binding protein an acute phase protein in monitoring critically ill patients Miroslav Prucha1 Ivan Herold2 Roman Zazula3 Ladislava Dubska1 Miroslav Dostal1 Thomas Hildebrand1 and Josef Hyanek4 1Staff Department of Clinical Biochemistry Hematology and Immunology Hospital Na Homolce Czech Republic 2Head Department of Anesthesiology and Intensive Care Medicine Klaudian s Hospital - Mlada Boleslav Czech Republic 3Head Department of Anesthesiology and Intensive Care Thomayer s Hospital Prague Czech Republic 4Head Department of Clinical Biochemistry Hematology and Immunology Hospital Na Homolce Czech Republic Correspondence Miroslav Prucha miroslav.prucha@homolka.cz Received 29 November 2002 Revisions requested 3 February 2003 Revisions received 18 August 2003 Accepted 2 September 2003 Published 1 October 2003 Critical Care 2003 7 R154-R159 DOI 10.1186 cc2386 This article is online at http ccforum.com content 7 6 R154 2003 Prucha et al. licensee BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Introduction The present study was conducted to assess the value of serum concentration of lipopolysaccharide-binding protein LBP in patients with systemic inflammatory response syndrome SIRS sepsis and septic shock with respect to its ability to differentiate between infectious and noninfectious etiologies in SIRS and to predict prognosis. Methods This prospective cohort study was conducted in a multidisciplinary intensive care unit. Sixtyeight patients admitted consecutively to the intensive care unit and who met criteria for SIRS sepsis or septic shock were included. Serum LBP was measured using an immunochemiluminiscence assay. Results Serum levels of