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Báo cáo y học: "Science review: Extracellular acidosis and the immune response: clinical and physiologic implications"

AvailTuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Science review: Extracellular acidosis and the immune response: clinical and physiologic implications. | Available online http ccforum.eom content 8 5 331 Review Science review Extracellular acidosis and the immune response clinical and physiologic implications John A Kellum1 Mingchen Song2 and Jinyou Li3 Associate Professor Critical Care Medicine and Medicine Co-Director The MANTRA Mechanisms And Novel Therapies for Resuscitation and Acute illness Laboratory Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA 2Research Fellow Department of Critical Care Medicine The MANTRA Laboratory Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA 3Visiting Researcher Department of Critical Care Medicine The MANTRA Laboratory Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA Corresponding author John A Kellum kellumja@ccm.upmc.edu Published online 16 June 2004 This article is online at http ccforum.com content 8 5 331 2004 BioMed Central Ltd Critical Care 2004 8 331-336 DOI 10.1186 cc2900 Abstract Metabolic acidosis is among the most common abnormalities seen in patients suffering from critical illness. Its etiologies are multiple and treatment of the underlying condition is the mainstay of therapy. However growing evidence suggests that acidosis itself has profound effects on the host particularly in the area of immune function. Given the central importance of immune function to the outcome of critical illness there is renewed interest in elucidating the effects of this all too common condition on the immune response. In this review we concentrate on the effects of extracellular acids on production and release of inflammatory mediators and we demonstrate that different acids produce different effects despite similar extracellular pH. Finally we discuss potential clinical implications. Keywords acidosis cytokines immune response pH sepsis Introduction Critical illness is exemplified by a state of profound .