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Báo cáo y học: "Altered immune parameters in chronic alcoholic patients at the onset of infection and of septic shock"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Altered immune parameters in chronic alcoholic patients at the onset of infection and of septic shock. | Available online http ccforum.eom content 8 5 R312 Research Altered immune parameters in chronic alcoholic patients at the onset of infection and of septic shock Vera von Dossow Corinna Schilling Stefan Beller Ortrud Vargas Hein Christian von Heymann Wolfgang J Kox and Claudia D Spies Open Access Department of Anesthesiology and Intensive Care Medicine Charité - Universitatsmedizin Berlin Berlin Germany Corresponding author Claudia D Spies claudia.spies@charite.de Received 02 February 2004 Revisions requested 23 March 2004 Revisions received 24 May 2004 Accepted 15 June 2004 Published 20 July 2004 Critical Care 2004 8 R312-R321 DOI 10.1186 cc2911 This article is online at http ccforum.com content 8 5 R31 2 2004 Dossow et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL Abstract Introduction Chronic alcoholic patients have a threefold to fourfold increased risk for developing a severe infection or septic shock after surgery which might be due to altered immune response. The aim of this outcome matched study was to investigate proinflammatory and anti-inflammatory immune parameters during the course of infection and subsequent septic shock in chronic alcoholic patients and to compare these parameters with those in nonalcoholic patients. Methods Twenty-eight patients from a cohort of fifty-six with either pneumonia or peritonitis and subsequent septic shock were selected. Fourteen patients were chronic alcoholics whereas fourteen were nonalcoholic patients. Chronic alcoholic patients met criteria Diagnostic and Statistical Manual of Mental Disorders IV of the American Psychiatric Association for alcohol abuse or dependence. Measurements were performed during the onset of infection within 24 hours after the onset of infection in early septic shock within 12 hours after onset of septic shock