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Báo cáo y học: "Clinical review: Treatment of heat stroke: should dantrolene be considered"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Clinical review: Treatment of heat stroke: should dantrolene be considered? | Critical Care February 2005 Vol 9 No 1 Hadad et al. Review Clinical review Treatment of heat stroke should dantrolene be considered Eran Hadad1 Yoav Cohen-Sivan1 Yuval Heled1 and Yoram Epstein2 1 Heller Institute of Medical Research Sheba Medical Center Tel Hashomer Israel 2Heller Institute of Medical Research Sheba Medical Center Tel Hashomer and the Sackler Faculty of Medicine Tel-Aviv University Tel-Aviv Israel Corresponding author Yoram Epstein hlrinst@post.tau.ac.il Published online 11 August 2004 This article is online at http ccforum.com content 9 1 86 2004 BioMed Central Ltd See Commentary page 23 Critical Care 2005 9 86-91 DOI 10.1186 cc2923 Abstract Rapid and efficient cooling is the most important therapeutic objective in patients with heat stroke HS . This article reviews the mechanism of action and rationale for the use of dantrolene as a potential supportive cooling method in the treatment of HS. Relevant studies were included to support discussion of the role of dantrolene for the treatment of HS. In some studies dantrolene was shown to accelerate cooling rate when administered after the development of exertional HS. Dantrolene was also found to be effective in reducing the extent of HS signs when given as pretreatment in an animal model. Accumulated data do not support the routine use of dantrolene as an adjuvant cooling technique in HS but administration of this drug in severe cases or in which no improvement is observed appears rational. Further trials are needed in order to assess the true effectiveness of dantrolene in HS. Keywords cooling dantrolene exertional heat stroke heat stroke hyperthermia temperature Introduction Hyperthermia is defined as any core temperature rise to above the hypothalamic set-point at which heat-dissipating mechanisms are impaired. Normal core temperature values are in the 36.5-37.5 C range at rest and can rise to 40 C during strenous exercise. Hyperthermia is usually caused by an imbalance between total heat .