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Báo cáo y học: "Effects of lornoxicam on the physiology of severe sepsis."

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Effects of lornoxicam on the physiology of severe sepsis. | Available online http ccforum.eom content 8 6 R474 Research Effects of lornoxicam on the physiology of severe sepsis Dilek Memis1 Beyhan Karamanlioglu2 Alparslan Turan1 Onur Koyuncu1 and Zafer Pamukọu2 Open Access Associate Professor Department of Anaesthesiology and Reanimation Medical Faculty Trakya University Edirne Turkey 2Professor Department of Anaesthesiology and Reanimation Medical Faculty Trakya University Edirne Turkey Corresponding author Dilek Memiậ dilmemis@mynet.com Received 1 March 2004 Revisions requested 2 May 2004 Revisions received 24 August 2004 Accepted 2 September 2004 Published 27 October 2004 Critical Care 2004 8 R474-R482 DOI 10.1186 cc2969 This article is online at http ccforum.com content 8 6 R474 2004 Memis et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Abstract Introduction The purpose of the present study was to evaluate the effects of intravenous lornoxicam on haemodynamic and biochemical parameters serum cytokine levels and patient outcomes in severe sepsis. Methods A total of 40 patients with severe sepsis were included and were randomly assigned 20 per group to receive either lornoxicam 8 mg administered intravenously every 12 hours for six doses or placebo. For both groups the following were recorded haemodynamic parameters heart rate mean arterial pressure nasopharyngeal body temperature arterial blood gas changes pH partial oxygen tension partial carbon dioxide tension plasma cytokine levels IL-1P IL-2 receptor IL-6 IL-8 tumour necrosis factor-a biochemical parameters lactate leucocytes trombocytes creatinine total bilirubin serum glutamate oxalate transaminase length of stay in the intensive care unit duration of mechanical ventilation and mortality. All measurements were obtained at .