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Báo cáo khoa học: "The epidemiology of severe sepsis in England, Wales and Northern Ireland, 1996 to 2004: secondary analysis of a high quality clinical"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The epidemiology of severe sepsis in England, Wales and Northern Ireland, 1996 to 2004: secondary analysis of a high quality clinical. | Available online http ccforum.eom content 10 2 R42 Research The epidemiology of severe sepsis in England Wales and Northern Ireland 1996 to 2004 secondary analysis of a high quality clinical database the ICNARC Case Mix Programme Database David A Harrison1 Catherine A Welch1 and Jane M Eddleston2 Open Access intensive Care National Audit Research Centre ICNARC Tavistock House Tavistock Square London WC1H 9HR UK 2Manchester Royal Infirmary Oxford Road Manchester M13 9WL UK Corresponding author David A Harrison david.harrison@icnarc.org Received 25 Oct 2005 Revisions requested 5 Dec 2005 Revisions received 6 Feb 2006 Accepted 1 4 Feb 2006 Published 1 0 Mar 2006 Critical Care 2006 10 R42 doi 10.1186 cc4854 This article is online at http ccforum.com content 10 2 R42 2006 Harrison et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction To evaluate the impact of recent evidence-based treatments for severe sepsis in routine clinical care requires an understanding of the underlying epidemiology particularly with regard to trends over time. We interrogated a high quality clinical database to examine trends in the incidence and mortality of severe sepsis over a nine-year period. Methods Admissions with severe sepsis occurring at any time within 24 hours of admission to critical care were identified to an established methodology using raw physiological data from the Intensive Care National Audit Research Centre ICNARC Case Mix Programme Database containing data from 343 860 admissions to 172 adult general critical care units in England Wales and Northern Ireland between December 1995 and January 2005. Generalised linear models were used to assess changes in the incidence case mix outcomes and activity of these .