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Báo cáo khoa học: "Surfactant therapy for acute respiratory failure in children: a systematic review and meta-analysis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Surfactant therapy for acute respiratory failure in children: a systematic review and meta-analysis. | Available online http ccforum.eom content 11 3 R66 Research Surfactant therapy for acute respiratory failure in children a systematic review and meta-analysis Mark Duffett1 Karen Choong1 Vivian Ng2 Adrienne Randolph3 and Deborah J Cook4 Department of Critical Care McMaster Children s Hospital 1 200 Main St. W. Hamilton Ontario L8S 4J9 Canada 2Grand River Hospital 835 King St. West Kitchener Ontario N2G 1G3 Canada Children s Hospital Boston 300 Longwood Avenue MSICU FA-108 Boston MA 02115 USA department of Clinical Epidemiology and Statistics McMaster University 1200 Main St. W. Hamilton Ontario L8N 3Z5 Canada Corresponding author Mark Duffett duffett@hhsc.ca Received 16 Mar 2007 Revisions requested 13 Apr 2007 Revisions received 11 May 2007 Accepted 15 Jun 2007 Published 15 Jun 2007 Critical Care 2007 11 R66 doi 10.1186 cc5944 This article is online at http ccforum.com content 11 3 R66 2007 Duffett et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Exogenous surfactant is used to treat acute respiratory failure in children although the benefits and harms in this setting are not clear. The objective of the present systematic review is to assess the effect of exogenous pulmonary surfactant on all-cause mortality in children mechanically ventilated for acute respiratory failure. Methods We searched the MEDLINE EMBASE CINAHL and Ovid Healthstar databases the bibliographies of included trials and review articles conference proceedings and trial registries. We included prospective randomized controlled trials of pulmonary surfactant that enrolled intubated and mechanically ventilated children with acute respiratory failure. We excluded trials that exclusively enrolled neonates or patients .