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Báo cáo y học: "Impaired nuclear import and viral incorporation of Vpr derived from a HIV long-term non-progressor"

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Impaired nuclear import and viral incorporation of Vpr derived from a HIV long-term non-progressor. | Retrovirology BioMed Central Open Access Short report Impaired nuclear import and viral incorporation of Vpr derived from a HIV long-term non-progressor Leon Caly1 Nitin K Saksena2 Sabine C Piller3 4 and David A Jans 1 Address Department of Biochemistry and Molecular Biology Monash University Clayton Victoria 3800 Australia 2Retroviral Genetics Division Centre for Virus Research Westmead Millennium Institute Westmead Hospital The University of Sydney Darcy Road Westmead N.S.W 2145 Australia 3HIV Protein Function and Interactions Group Centre for Virus Research Westmead Millennium Institute Westmead Hospital The University of Sydney Darcy Road Westmead N.S.W 2145 Australia and 4University of Western Sydney Penrith South DC N.S.W 1797 Australia Email Leon Caly - leon.caly@med.monash.edu.au Nitin K Saksena - nitin_saksena@wmi.usyd.edu.au Sabine C Piller - S.Piller@uws.edu.au David A Jans - david.jans@med.monash.edu.au Corresponding author Published 18 July 2008 Received 18 January 2008 Retrovirology 2008 5 67 doi 10.1186 1742-4690-5-67 Accepted 18 July 2008 This article is available from http www.retrovirology.cOm content 5 1 67 2008 Caly et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ We previously reported an epidemiologically linked HIV-1 infected patient cohort in which a longterm non-progressor LTNP infected two recipients who then exhibited normal disease progression. Expression of patient-derived vpr sequences from each of the three cohort members in mammalian cells tagged with GFP revealed a significant reduction in Vpr nuclear import and virion incorporation uniquely from the LTNP whereas Vpr from the two progressing .

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