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Báo cáo y học: " The contribution of peroxynitrite generation in HIV replication in human primary macrophages"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: The contribution of peroxynitrite generation in HIV replication in human primary macrophages. | BioMed Central Retrovirology Research Open Access The contribution of peroxynitrite generation in HIV replication in human primary macrophages Stefano Aquaro41 2 Carolina Muscolit3 4 Alessandro Ranazzi 1 Michela Pollicita1 Teresa Granato5 Laura Masuelli1 Andrea Modesti1 Carlo- Federico Perno1 and Vincenzo Mollace 3 4 6 Address Department of Experimental Medicine and Biochemical Sciences University of Tor Vergata Rome Italy 2Department of Pharmaco-Biology University of Calabria Rende CS Italy 3Faculty of Pharmacy University of Catanzaro Magna Graecia Roccelletta di Borgia Catanzaro Italy 4San Raffaele Pisana IRCCS Rome Italy 5IBPM-CNR Rome Italy and 6Istitute Mondino-Tor Vergata Rome Italy Email Stefano Aquaro - aquaro@uniroma2.it Carolina Muscoli - muscoli@fastwebnet.it Alessandro Ranazzi - ranazzi@uniroma2.it Michela Pollicita - pollicita@uniroma2.it Teresa Granato - granato@libero.it Laura Masuelli - masuelli@uniroma1.it Andrea Modesti - modesti@uniroma2.it Carlo-Federico Perno - perno@uniroma2.it Vincenzo Mollace - mollace@unicz.it Corresponding author tEqual contributors Published 21 October 2007 Received 26 December 2006 Accepted 21 October 2007 Retrovirology 2007 4 76 doi l0.ll86 l 742-4690-4-76 This article is available from http www.retrovirology.cOm content 4 1 76 2007 Aquaro et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Monocytes Macrophages M M play a pivotal role as a source of virus during the whole course of HIV-1 infection. Enhanced oxidative stress is involved in the pathogenesis of HIV- 1 infection. HIV-1 regulatory proteins induce a reduction of the expression and the activity of MnSOD the mitochondrial isoform leading to a sustained generation of superoxide anions and .