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Báo cáo y học: " The histone chaperone protein Nucleosome Assembly Protein-1 (hNAP-1) binds HIV-1 Tat and promotes viral transcription"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " The histone chaperone protein Nucleosome Assembly Protein-1 (hNAP-1) binds HIV-1 Tat and promotes viral transcription. | Retrovirology BioMed Central Research Open Access The histone chaperone protein Nucleosome Assembly Protein-1 hNAP-1 binds HIV-1 Tat and promotes viral transcription Chiara Vardabasso1 Lara Manganaro1 Marina Lusic1 Alessandro Marcello2 and Mauro Giacca 1 Address 1Molecular Medicine Laboratory International Centre for Genetic Engineering and Biotechnology ICGEB Padriciano 99 34012 Trieste Italy and 2Molecular Virology Laboratory International Centre for Genetic Engineering and Biotechnology ICGEB Padriciano 99 34012 Trieste Italy Email Chiara Vardabasso - vardabas@icgeb.org Lara Manganaro - manganar@icgeb.org Marina Lusic - lusic@icgeb.org Alessandro Marcello - marcello@icgeb.org Mauro Giacca - giacca@icgeb.org Corresponding author Published 28 January 2008 Received I October 2007 Retrovirology 2008 5 8 doi 10.1186 1742-4690-5-8 Accepted 28 January 2008 This article is available from http www.retrovirology.com content 5 I 8 2008 Vardabasso et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.Org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Despite the large amount of data available on the molecular mechanisms that regulate HIV-1 transcription crucial information is still lacking about the interplay between chromatin conformation and the events that regulate initiation and elongation of viral transcription. During transcriptional activation histone acetyltransferases and ATP-dependent chromatin remodeling complexes cooperate with histone chaperones in altering chromatin structure. In particular human Nucleosome Assembly Protein-1 hNAP-1 is known to act as a histone chaperone that shuttles histones H2A H2B into the nucleus assembles nucleosomes and promotes chromatin fluidity thereby affecting transcription of several cellular genes. Results Using a .