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Báo cáo y học: "Circulating monocytes from healthy individuals and COPD patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Circulating monocytes from healthy individuals and COPD patients | Respiratory Research BioMed Central Research Open Access Circulating monocytes from healthy individuals and COPD patients Ruta Aldonyte1 Lennart Jansson2 Eeva Piitulainen3 and Sabina Janciauskiene 1 Address Department of Internal Medicine University Hospital Malmo Sweden 2Experimental Medicine Astra Zeneca Lund Sweden and 3Department of Respiratory Medicine University Hospital Malmo Sweden Email Ruta Aldonyte - ruta.dominaitiene@medforsk.mas.lu.se Lennart Jansson - Lennart.Jansson@astrazeneca.com Eeva Piitulainen - Eeva.Piitulainen@lung.mas.lu.se Sabina Janciauskiene - sabina.janciauskiene@medforsk.mas.lu.se Corresponding author Published 22 September 2003 Received 03 July 2003 Accepted 22 September 2003 Respiratory Research 2003 4 11 This article is available from http respiratory-research.cOm content 4 1 1 1 2003 Aldonyte et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Background Chronic obstructive pulmonary disease COPD is characterized by incompletely reversible airflow obstruction associated with inflammation in which monocytes macrophages are the predominant inflammatory cells. The only known genetic factor related to COPD is inherited PiZZ deficiency of a 1-antitrypsin AAT an inhibitor of serine proteases. Methods We investigated the basal and LPS-stimulated release of pro-inflammatory molecules from blood monocytes isolated from age and gender matched healthy n 30 and COPD n 20 individuals with and without AAT deficiency. Results After 18 h of cell culture the basal release of MMP-9 was 2.5-fold p 0.02 greater whereas IL-8 was 1.8-fold p 0.01 lower from COPD patient monocytes than from controls. LPS-stimulated release of IL-6 and MCP-1 was greater from COPD patient s monocytes relative to controls while activation of control cells resulted in enhanced secretion of