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Báo cáo y học: " Specific TATAA and bZIP requirements suggest that HTLV-I Tax has transcriptional activity subsequent to the assembly of an initiation complex"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Specific TATAA and bZIP requirements suggest that HTLV-I Tax has transcriptional activity subsequent to the assembly of an initiation complex | Retrovirology BioMed Central Research Open Access Specific TATAA and bZIP requirements suggest that HTLV-I Tax has transcriptional activity subsequent to the assembly of an initiation complex Yick-Pang Ching1 2 Abel CS Chun1 King-Tung Chin1 Zhi-Qing Zhang3 Kuan-Teh Jeang and Dong-Yan Jin 4 Address Department of Biochemistry The University of Hong Kong Pokfulam Hong Kong China 2Department of Pathology The University of Hong Kong Pokfulam Hong Kong China 3National Key Laboratory for Molecular Virology Institute of Virology 100 Yingxin Street Beijing 100052 China and 4Laboratory of Molecular Microbiology National Institutes of Health 9000 Rockville Pike Bethesda MD 20892-0460 USA Email Yick-Pang Ching - ypching@hkucc.hku.hk Abel CS Chun - cschun@hkusua.hku.hk King-Tung Chin - tonychin@hkusua.hku.hk Zhi-Qing Zhang - zhangzq@public3.bta.net.cn Kuan-Teh Jeang - kj7e@nih.gov Dong-Yan Jin - dyjin@hkucc.hku.hk Corresponding author Published 30 July 2004 Received 27 May 2004 Retrovirology 2004 1 18 doi 10.1186 1742-4690-1-18 Accepted 30 July 2004 This article is available from http www.retrovirology.cOm content 1 1 18 2004 Ching et al licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Human T-cell leukemia virus type I HTLV-I Tax protein is a transcriptional regulator of viral and cellular genes. In this study we have examined in detail the determinants for Tax-mediated transcriptional activation. Results Whereas previously the LTR enhancer elements were thought to be the sole Tax-targets herein we find that the core HTLV-I TATAA motif also provides specific responsiveness not seen with either the SV40 or the E1b TATAA boxes. When enhancer elements which can mediate Taxresponsiveness were compared the authentic .