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Báo cáo y học: "Synthesis of acute phase proteins in rats with cirrhosis exposed to lipopolysaccharide"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Synthesis of acute phase proteins in rats with cirrhosis exposed to lipopolysaccharide. | Comparative Hepatology BioMed Central Research Synthesis of acute phase proteins in rats with cirrhosis exposed to lipopolysaccharide Susanne Schouw Nielsen 1 Thorbjorn Grofte1 Niels Tygstrup2 and Hendrik Vilstrup1 Open Access Address Department of Medicine V Hepatology Gastroenterology Aarhus University Hospital Noerrebrogade 44 DK-8000 Aarhus C Denmark and 2Department of Medicine A State University Hospital 2100 Copenhagen Denmark Email Susanne Schouw Nielsen - ssnie@as.aaa.dk Thorbjorn Grofte - grofte@akhphd.au.dk Niels Tygstrup - tygstrup@dadlnet.dk Hendrik Vilstrup - hvils@as.aaa.dk Corresponding author Published 12 September 2006 Received 21 December 2005 - . n .1 r - r Accepted 12 September 2006 Comparative Hepatology 2006 5 3 doi l0.ll86 l476-5926-5-3 This article is available from http www.comparative-hepatology.cOm content 5 1 3 2006 Nielsen et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In patients with cirrhosis infection is frequent and a leading cause of death. This is secondary to various immunologic abnormalities in both the innate and the adaptive immune system. However it remains unclear whether cirrhosis affects the inflammatory systemic component of the innate immunity the acute phase response mostly effectuated by the liver itself. We hypothesized that rats with cirrhosis raise a reduced acute phase response induced by lipopolysaccharide LPS . Results We examined the acute phase response induced by intraperitoneal injection of a low dose of LPS in sham operated control animals and in rats with liver cirrhosis induced by bile duct ligation BDL . We measured the serum concentrations of the most important acute phase proteins and their liver tissue gene expressions assessed by .