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Báo cáo y học: " Interactions Between Estrogen- and Ah-Receptor Signalling Pathways in Primary Culture of Salmon Hepatocytes Exposed to Nonylphenol and 3,3',4,4'-Tetrachlorobiphenyl (Congener 77)"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Interactions Between Estrogen- and Ah-Receptor Signalling Pathways in Primary Culture of Salmon Hepatocytes Exposed to Nonylphenol and 3,3',4,4'-Tetrachlorobiphenyl (Congener 77). | Comparative Hepatology BioMed Central Open Access Interactions Between Estrogen- and Ah-Receptor Signalling Pathways in Primary Culture of Salmon Hepatocytes Exposed to Nonylphenol and 3 3 4 4 -Tetrachlorobiphenyl Congener 77 Anne S Mortensen and Augustine Arukwe Address Department of Biology Norwegian University of science and Technology NTNU Hogskoleringen 5 7491 Trondheim Norway Email Anne S Mortensen - anne.mortensen@bio.ntnu.no Augustine Arukwe - arukwe@bio.ntnu.no Corresponding author Published 13 April 2007 Received 11 December 2006 Comparative Hepatology 2007 6 2 doi 10.1186 1476-5926-6-2 Accepted 13 April 2007 This article is available from http www.comparative-hepatology.cOm content 6 1 2 2007 Mortensen and Arukwe licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The estrogenic and xenobiotic biotransformation gene expressions are receptor-mediated processes that are ligand structure-dependent interactions with estrogen-receptor ER and aryl hydrocarbon receptor AhR probably involving all subtypes and other co-factors. The anti-estrogenic activities of AhR agonists have been reported. In teleost fish exposure to AhR agonists has been associated with reduced Vtg synthesis or impaired gonadal development in both in vivo- and in vitro studies. Inhibitory AhR and ER cross-talk have also been demonstrated in breast cancer cells rodent uterus and mammary tumors. Previous studies have shown that AhR-agonists potentiate xenoestrogen-induced responses in fish in vivo system. Recently several studies have shown that AhR-agonists directly activate ERa and induce estrogenic responses in mammalian in vitro systems. In this study two separate experiments were performed to study the molecular interactions .