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Báo cáo y học: "Effects of Sophora japonica flowers (Huaihua) on cerebral infarction"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Effects of Sophora japonica flowers (Huaihua) on cerebral infarction. | Chen and Hsieh Chinese Medicine 2010 5 34 http www.cmjournal.Org content 5 1 34 CHINESE MEDICINE REVIEW Open Access Effects of Sophora japonica flowers Huaihua on cerebral infarction Hsiang-Ni Chen1 Ching-Liang Hsieh1 2 3 Abstract The dried flowers and buds of Sophora japonica are used as a medicinal herb in China Japan and Korea to treat bleeding hemorrhoids and hematemesis. This article presents an overview of the effects of Sophora japonica on cerebral infarction based on literature searched from Medline PubMed Cochrane Library and the China National Knowledge Infrastructure CNKI . Sophora japonica contains both anti-hemorrhagic and anti-hemostatic substances. Sophora japonica reduces cerebral infarction partly as a result of its anti-oxidative and anti-inflammatory activities. Previous studies found that Sophora japonica reduced the size of cerebral infarction and neurological deficits and reduced microglial activation interleukin-1p release and number of apoptotic cells in ischemia-reperfusion injured Sprague-Dawley rats. Further study is required to determine the relationship between Sophora japonica-mediated reduction in cerebral infarction size and the effects of Sophora japonica on platelet aggregation and cardiovascular function. Background Dried flowers and buds of Sophora japonica Huaihua are a medicinal herb used in China Japan and Korea to treat hemorrhoids and hematemesis 1 . Main components of Sophora japonica include flavones tetraglycosides isoflavones isoflavone tetraglycosides triterpene glycosides phospholipids alkaloids amino acids and polysaccharides 2 . Moreover Sophora japonica contains five main flavonoids of rutin quercetin isorhamnetin isorhamnetin genistein and kaempferol 2 . This article aims to provide an overview of the pharmacology of Sophora japonica in particular its effects and mechanisms in reducing cerebral infarction Table 1 . To this end we searched the English language databases namely Medline PubMed Cochrane Library and .