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Báo cáo y học: "Effects of steroids on reintubation and post-extubation stridor in adults: meta-analysis of randomised controlled trials"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Effects of steroids on reintubation and post-extubation stridor in adults: meta-analysis of randomised controlled trials. | Available online http ccforum.eom content 13 2 R49 Research Effects of steroids on reintubation and post-extubation stridor in adults meta-analysis of randomised controlled trials Samir Jaber1 Boris Jung1 Gérald Chanques1 Francis Bonnet2 and Emmanuel Marret2 Open Access 1 Department of Anaesthesiology and Critical Care University Saint Eloi Hospital 80 avenue Augustin Fliche University of Montpellier I 34295 Montpellier Cedex 5 France department of Anesthesiology and Critical Care Tenon University Hospital Assistance Publique Hôpitaux de Paris and INSERM U 707 Université Pierre et Marie Curie Paris 6 Paris France Corresponding author Samir Jaber s-jaber@chu-montpellier.fr Received 5 Dec 2008 Revisions requested 9 Jan 2009 Revisions received 10 Feb 2009 Accepted 3 Apr 2009 Published 3 Apr 2009 Critical Care 2009 13 R49 doi 10.1186 cc7772 This article is online at http ccforum.com content 13 2 R49 2009 Jaber et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction The efficacy of steroid administration before planned tracheal extubation in critical care patients remains controversial with respect to the selection of patients most likely to benefit from this treatment. Methods We performed an extensive literature search for adult trials testing steroids versus placebo to prevent reintubation or laryngeal dyspnoea. Studies were evaluated on a five-point scale based on randomisation double-blinding and follow-up. Our analysis included trials having a score three or higher with patients mechanically ventilated for at least 24 hours and treated with steroids before extubation taking into account the time of their administration early vs late and if the population selected was at risk or not. Results Seven .