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Báo cáo y học: " Utility of a single adjusting compartment: a novel methodology for whole body physiologically-based pharmacokinetic modelling"

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Utility of a single adjusting compartment: a novel methodology for whole body physiologically-based pharmacokinetic modelling | Theoretical Biology and Medical Modelling BioMed Central Research Utility of a single adjusting compartment a novel methodology for whole body physiologically-based pharmacokinetic modelling Hirotaka Ando 1 Shigeru Izawa1 Wataru Hori2 and Ippei Nakagawa1 Address discovery Research Laboratories Kyorin Pharmaceutical Co. Ltd. Tochigi Japan and 2PM Office Research Headquarters Kyorin Pharmaceutical Co. Ltd. Tokyo Japan Email Hirotaka Ando - hirotaka.andou@mb.kyorin-pharm.co.jp Shigeru Izawa-shigeru.izawa@mb.kyorin-pharm.co.jp Wataru Hori - wataru.hori@mb.kyorin-pharm.co.jp Ippei Nakagawa - ippei.nakagawa@mb.kyorin-pharm.co.jp Corresponding author Open Access Published 8 August 2008 Received 15 April 2008 Theoretical Biology and Medical Modelling 2008 5 19 doi 10.1186 1742-4682-5-19 Accepted 8 August 2008 This article is available from http www.tbiomed.cOm content 5 1 19 2008 Ando et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background There are various methods for predicting human pharmacokinetics. Among these a whole body physiologically-based pharmacokinetic WBPBPK model is useful because it gives a mechanistic description. However WBPBPK models cannot predict human pharmacokinetics with enough precision. This study was conducted to elucidate the primary reason for poor predictions by WBPBPK models and to enable better predictions to be made without reliance on complex concepts. Methods The primary reasons for poor predictions of human pharmacokinetics were investigated using a generic WBPBPK model that incorporated a single adjusting compartment SAC a virtual organ compartment with physiological parameters that can be adjusted arbitrarily. The blood flow rate organ volume and the steady state tissue-plasma

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