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Báo cáo y học: "Evolution of insect proteomes: insights into synapse organization and synaptic vesicle life cycle"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Evolution of insect proteomes: insights into synapse organization and synaptic vesicle life cycle. | Open Access Research Evolution of insect proteomes insights into synapse organization and synaptic vesicle life cycle Chava Yanay Noa Morpurgo and Michal Linial Address Department of Biological Chemistry Institute of Life Sciences Givat Ram Campus Hebrew University of Jerusalem Jerusalem 91904 Israel. n These authors contributed equally to this work. Correspondence Michal Linial. Email michall@cc.huji.ac.il Published 7 February 2008 Genome Biology 2008 9 R27 doi 10.1 186 gb-2008-9-2-r27 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2008 9 2 R27 Received 27 September 2007 Revised 6 December 2007 Accepted 7 February 2008 2008 Yanay et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The molecular components in synapses that are essential to the life cycle of synaptic vesicles are well characterized. Nonetheless many aspects of synaptic processes in particular how they relate to complex behaviour remain elusive. The genomes of flies mosquitoes the honeybee and the beetle are now fully sequenced and span an evolutionary breadth of about 350 million years this provides a unique opportunity to conduct a comparative genomics study of the synapse. Results We compiled a list of 120 gene prototypes that comprise the core of presynaptic structures in insects. Insects lack several scaffolding proteins in the active zone such as bassoon and piccollo and the most abundant protein in the mammalian synaptic vesicle namely synaptophysin. The pattern of evolution of synaptic protein complexes is analyzed. According to this analysis the components of presynaptic complexes as well as proteins that take part in organelle biogenesis are tightly coordinated. .