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Báo cáo y học: "Computational identification of obligatorily autocatalytic replicators embedded in metabolic networks"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Computational identification of obligatorily autocatalytic replicators embedded in metabolic networks. | Open Access Research Computational identification of obligatorily autocatalytic replicators embedded in metabolic networks Ádám Kun Balazs Papp and Eõrs Szathmáry Addresses Collegium Budapest Institute for Advanced Study Szentháromság utca 2 Budapest H-1014 Hungary. Department of Plant Taxonomy and Ecology Institute of Biology Eõtvõs University Pázmány Péter sétány 1 C Budapest H-1117 Hungary. Faculty of Life Sciences The University of Manchester Oxford Road Manchester M13 9PT UK. Parmenides Center for the Study of Thinking Kardinal Faulhaber Strasse Munich D-80333 Germany. Current address Institute of Biochemistry Biological Research Center Szeged H-6701 Hungary. Correspondence Balázs Papp. Email pappb@brc.hu Published 10 March 2008 Received 26 September 2007 Genome Biology 2008 9 R51 doi l0.ll86 gb-2008-9-3-r5l R .d. J5 January.2008 gy g Accepted 10 March 2008 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2008 9 3 R5l 2008 Kun et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background If chemical A is necessary for the synthesis of more chemical A then A has the power of replication such systems are known as autocatalytic systems . We provide the first systems-level analysis searching for small-molecular autocatalytic components in the metabolisms of diverse organisms including an inferred minimal metabolism. Results We find that intermediary metabolism is invariably autocatalytic for ATP. Furthermore we provide evidence for the existence of additional organism-specific autocatalytic metabolites in the forms of coenzymes NAD coenzyme A tetrahydrofolate quinones and sugars. Although the enzymatic reactions of a number of autocatalytic cycles are