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Báo cáo y học: " Evolution of selenium utilization traits"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Evolution of selenium utilization traits. | Research Open Access Evolution of selenium utilization traits Héctor Romero Yan Zhang Vadim N Gladyshev and Gustavo Salinas Addresses Laboratorio de Organization y Evolution del Genoma Dpto. de Biología Celular y Molecular Instituto de Biología Facultad de Ciencias Iguá 4225 Montevideo CP 11400 Uruguay. Escuela Universitaria de Tecnología Médica Facultad de Medicina Piso 3 Hospital de Clínicas Avda. Italia s n Montevideo CP 11600 Uruguay. Department of Biochemistry University of Nebraska Lincoln NE 68588-0664 USA. Cátedra de Inmunología Facultad de Química Ciencias Instituto de Higiene Avda. A. Navarro 3051 Montevideo CP 11600 Uruguay. Correspondence Gustavo Salinas. E-mail gsalin@fq.edu.uy Published 27 July 2005 Genome Biology 2005 6 R66 doi 10.1 186 gb-2005-6-8-r66 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2005 6 8 R66 Received 20 April 2005 Revised 7 June 2005 Accepted 27 June 2005 2005 Romero et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The essential trace element selenium is used in a wide variety of biological processes. Selenocysteine Sec the 21st amino acid is co-translationally incorporated into a restricted set of proteins. It is encoded by an UGA codon with the help of tRNASec SelC Secspecific elongation factor SelB and a c s-acting mRNA structure SECIS element . In addition Sec synthase SelA and selenophosphate synthetase SelD are involved in the biosynthesis of Sec on the tRNASec. Selenium is also found in the form of 2-selenouridine a modified base present in the wobble position of certain tRNAs whose synthesis is catalyzed by YbbB using selenophosphate as a precursor. Results We analyzed completely sequenced .