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Báo cáo y học: "Adenovirus type 5 exerts genome-wide control over cellular programs governing proliferation, quiescence, and survival"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Adenovirus type 5 exerts genome-wide control over cellular programs governing proliferation, quiescence, and survival. | Open Access Research Adenovirus type 5 exerts genome-wide control over cellular programs governing proliferation quiescence and survival Daniel L Miller Chad L Myers Brenden Rickards Hilary A Coller and S Jane Flint Addresses Department of Molecular Biology Princeton University Princeton NJ 08544 USA. Laboratory of Genetics University of Wisconsin 425-G Henry Mall Madison Wisconsin 53706 USA. Lewis-Sigler Institute for Integrative Genomics Carl Icahn Laboratory Princeton University Princeton NJ 08544 USA. Department of Computer Science Princeton University Princeton New Jersey 08544 USA. Correspondence S Jane Flint. Email sjflint@princeton.edu Published 12 April 2007 Genome Biology 2007 8 R58 doi 10.1 186 gb-2007-8-4-r58 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2007 8 4 R58 Received 4 August 2006 Revised 20 October 2006 Accepted 12 April 2007 2007 Miller et al licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Human adenoviruses such as serotype 5 Ad5 encode several proteins that can perturb cellular mechanisms that regulate cell cycle progression and apoptosis as well as those that mediate mRNA production and translation. However a global view of the effects of Ad5 infection on such programs in normal human cells is not available despite widespread efforts to develop adenoviruses for therapeutic applications. Results We used two-color hybridization and oligonucleotide microarrays to monitor changes in cellular RNA concentrations as a function of time after Ad5 infection of quiescent normal human fibroblasts. We observed that the expression of some 2 000 genes about 10 of those examined increased or decreased by a factor of two or greater .