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Báo cáo y học: " Profiling RE1/REST-mediated histone modifications in the human genome"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Profiling RE1/REST-mediated histone modifications in the human genome. | Researc h Open Access Profiling REI REST-mediated histone modifications in the human genome Deyou Zheng Keji Zhao and Mark F Mehler Addresses Institute for Brain Disorders and Neural Regeneration Department of Neurology Rose F Kennedy Center for the Study of Intellectual and Developmental Disabilities Albert Einstein College of Medicine Morris Park Avenue Bronx NY 10461 USA. Department of Genetics and Neuroscience Albert Einstein College of Medicine Morris Park Avenue Bronx NY 10461 USA. Laboratory of Molecular Immunology National Heart Lung and Blood Institute National Institute of Health Rockville Pike Bethesda MD 20892 USA. Departments of Neuroscience and Psychiatry and Behavioral Sciences Einstein Cancer Center Albert Einstein College of Medicine Morris Park Avenue Bronx NY 10461 USA. Correspondence Deyou Zheng. Email dzheng@aecom.yu.edu Published 27 January 2009 Received 24 November 2008 Genome Biology 2009 10 R9 doi 10.1186 gb-2009-10-1-r9 Accepted 27 January 2009 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2009 10 1 R9 2009 Zheng et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The transcriptional repressor REST RE1 silencing transcription factor also called NRSF for neuron-restrictive silencing factor binds to a conserved RE1 motif and represses many neuronal genes in non-neuronal cells. This transcriptional regulation is transacted by several nucleosome-modifying enzymes recruited by REST to RE1 sites including histone deacetylases for example HDAC1 2 demethylases for example LSD1 and methyltransferases for example G9a . Results We have investigated a panel of 38 histone modifications by ChIP-Seq analysis for REST-mediated .