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Báo cáo y học: "Genome duality Silvia Kocanova and Kerstin Bystricky Address: Laboratoire de Biologie Moléculaire Eucaryote"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Genome duality Silvia Kocanova and Kerstin Bystricky Address: Laboratoire de Biologie Moléculaire Eucaryote | Meeting report Genome duality Silvia Kocanova and Kerstin Bystricky Address Laboratoire de Biologie Moléculaire Eucaryote LBME University of Toulouse CNRS 118 route de Narbonne 31062 Toulouse France. Correspondence Kerstin Bystricky. Email kerstin@biotoul.fr Published 28 May 2009 Genome Biology 2009 10 308 doi 10.1186 gb-2009-10-5-308 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2009 10 5 308 2009 BioMed Central Ltd A report on Higher Order Genome Architecture the third meeting of the Marie Curie Conferences and Training Courses MC-GARD Edinburgh UK 1-5 April 2009. Epigenomics is the study of epigenetics in the nuclear environment. Understanding the interplay between gene expression and positioning of specific DNA sequences motivates intense research and animates vivid discussions. New tools to investigate this relationship on a genome-wide level are continuously being developed and in April the latest technological advances and some exciting recent results were presented at the latest Marie Curie meeting and training course held in Edinburgh. We present a few of the highlights here. Position is everything - or is it The intranuclear positions of several genes have been correlated with their activity. This observation led to the hypothesis that co-regulated genes might be recruited to preassembled transcription factories which are potentially nucleated around foci of shared transcription factors. It is unclear whether relocalization is a consequence of transcription or whether recruitment to a distinct site poises sequences for expression or silencing. The use of genome-wide DNA adenine methyltransferase identification Dam-ID has enabled Maarten Fornerod Netherlands Cancer Institute Amsterdam The Netherlands and Daan Hupkes Netherlands Cancer Institute to analyze the nature and dynamic behavior of the genome at the nuclear periphery in a clever way. Fornerod showed that in Drosophila genes tethered to