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Báo cáo y học: " Human embryonic stem cell (hES) derived dendritic cells are functionally normal and are susceptible to HIV-1 infection"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Human embryonic stem cell (hES) derived dendritic cells are functionally normal and are susceptible to HIV-1 infection. | AIDS Research and Therapy BioMed Central Research Open Access Human embryonic stem cell hES derived dendritic cells are functionally normal and are susceptible to HIV-1 infection Sriram Bandi1 2 and Ramesh Akkina 1 Address Department of Microbiology Immunology and Pathology Colorado State University Fort Collins Colorado 80523 USA and 2Department of Medicine Marion Bessin Liver Research Center and Center for Human Embryonic Stem Cell Research Albert Einstein College of Medicine Bronx New York 10461 USA Email Sriram Bandi - sbandi@aecom.yu.edu Ramesh Akkina - akkina@colostate.edu Corresponding author Published 23 January 2008 Received 31 October 2007 AIDS Research and Therapy 2008 5 1 doi 10.1186 1742-6405-5-1 Accepted 23 January 2008 This article is available from http www.aidsrestherapy.cOm content 5 1 1 2008 Bandi and Akkina licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Human embryonic stem hES cells hold considerable promise for cell replacement and gene therapies. Their remarkable properties of pluripotency self-renewal and tractability for genetic modification potentially allows for the production of sizeable quantities of therapeutic cells of the hematopoietic lineage. Dendritic cells DC arise from CD34 hematopoietic progenitor cells HPCs and are important in many innate and adaptive immune functions. With respect to HIV-1 infection DCs play an important role in the efficient capture and transfer of the virus to susceptible cells. With an aim of generating DCs from a renewable source for HIV-1 studies here we evaluated the capacity of hES cell derived CD34 cells to give rise to DCs which can support HIV-1 infection. Results Undifferentiated hES cells were cultured on S17 mouse bone marrow stromal