Đang chuẩn bị liên kết để tải về tài liệu:
Báo cáo y học: "Lipoprotein levels and cardiovascular risk in HIV-infected and uninfected Rwandan women"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Lipoprotein levels and cardiovascular risk in HIV-infected and uninfected Rwandan women. | Anastos et al. AIDS Research and Therapy 2010 7 34 http www.aidsrestherapy.eom content 7 1 34 AIDS RESEARCH AND THERAPY RESEARCH Open Access Lipoprotein levels and cardiovascular risk in HIV-infected and uninfected Rwandan women 1 -f- r r 1 2C r r r I r l I zd s m s Z t 3 h I í m I I 14 h r I_I f f z 5 11 I L I I c 16 I -s r z I s 7 s r7 Kathryn Anastos rrangois Ndamage Dalian Lu Marage H Cohen Qiuhu Shi Jason Lazar Venerand Bigirimana8 Eugene Mutimura9 Abstract Background Lipoprotein profiles in HIV-infected African women have not been well described. We assessed associations of lipoprotein levels and cardiovascular risk with HIV-infection and CD4 count in Rwandan women. Methods Cross-sectional study of 824 218 HIV-negative 606 HIV Rwandan women. Body composition by body impedance analysis CD4 count and fasting serum total cholesterol total-C triglycerides TG and high-density lipoprotein HDL levels were measured. Low-density lipoprotein LDL was calculated from Friedewald equation if TG 400 and measured directly if TG 400 mg dl. Results BMI was similar in HIV and -negative women 1 were diabetic and HIV women were younger. In multivariate models LDL was not associated with HIV-serostatus. HDL was lower in HIV women 44 vs. 54 mg dL p 0.0001 with no significant difference by CD4 count p 0.13 . HIV serostatus p 0.005 and among HIV women lower CD4 count p 0.04 were associated with higher TG. BMI was independently associated with higher LDL p 0.01 and higher total body fat was strongly associated with higher total-C and LDL. Framingham risk scores were 2 in both groups. Conclusions In this cohort of non-obese African women HDL and TG but not LDL were adversely associated with HIV infection. As HDL is a strong predictor of cardiovascular CV events in women this HIV-associated difference may confer increased risk for CV disease in HIV-infected women. Introduction Dyslipidemias have been described since 1989 in individuals with human immunodeficiency virus HIV infection in