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Báo cáo y học: " Markers of thrombogenesis are activated in unmedicated patients with acute psychosis: a matched case control study"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Markers of thrombogenesis are activated in unmedicated patients with acute psychosis: a matched case control study | Masopust et al. BMC Psychiatry 2011 11 2 http www.biomedcentral.eom 1471-244X 11 2 BMC Psychiatry RESEARCH ARTICLE Open Access Markers of thrombogenesis are activated in unmedicated patients with acute psychosis a matched case control study 1 2 3 4 1 1 Jiri Masopust Radovan Malý Ctirad Andrýs Martin Valis Jan Bazant Ladislav Hosák Abstract Background Antipsychotic treatment has been repeatedly found to be associated with an increased risk for venous thromboembolism in schizophrenia. The extent to which the propensity for venous thromboembolism is linked to antipsychotic medication alone or psychosis itself is unclear. The objective of this study was to determine whether markers of thrombogenesis are increased in psychotic patients who have not yet been treated with antipsychotic medication. Methods We investigated the plasma levels of markers indicating activation of coagulation D-dimers and Factor VIII and platelets soluble P-selectin sP-selectin in an antipsychotic-naive group of fourteen men and eleven women with acute psychosis age 29.1 8.3 years body mass index 23.6 4.7 and twenty-five healthy volunteers were matched for age gender and body mass index. Results D-dimers median 0.38 versus 0.19 mg l mean 1.12 2.38 versus 0.28 0.3 mg l P 0.003 and sP-selectin median 204.1 versus 112.4 ng ml mean 209.9 124 versus 124.1 32 P 0.0005 plasma levels were significantly increased in the group of patients with acute psychosis as compared with healthy volunteers. We found a trend median 148 versus 110 mean 160 72.5 versus 123 62.5 P 0.062 of increased plasma levels of factor VIII in psychotic patients as compared with healthy volunteers. Conclusions The results suggest that at least a part of venous thromboembolic events in patients with acute psychosis may be induced by pathogenic mechanisms related to psychosis rather than by antipsychotic treatment. Finding an exact cause for venous thromboembolism in psychotic patients is necessary for its effective treatment and .