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Báo cáo y học: " Profiles of cytokine and chemokine gene expression in human pulmonary epithelial cells induced by human and avian influenza viruses"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Profiles of cytokine and chemokine gene expression in human pulmonary epithelial cells induced by human and avian influenza viruses | Lam et al. Virology Journal 2010 7 344 http www.virologyj.eom content 7 1 344 VIROLOGY JOURNAL RESEARCH Open Access Profiles of cytokine and chemokine gene expression in human pulmonary epithelial cells induced by human and avian influenza viruses WY Lam1 Apple CM Yeung1 Ida MT Chu1 Paul KS Chan1 2 Abstract Influenza pandemic remains a serious threat to human health. In this study the repertoire of host cellular cytokine and chemokine responses to infections with highly pathogenic avian influenza H5N1 low pathogenicity avian influenza H9N2 and seasonal human influenza H1N1 were compared using an in vitro system based on human pulmonary epithelial cells. The results showed that H5N1 was more potent than H9N2 and H1N1 in inducing CXCL-10 IP-10 TNF-alpha and CCL-5 RANTES. The cytokine chemokine profiles for H9N2 in general resembled those of H1N1. Of interest only H1N1 but none of the avian subtypes examined could induce a persistent elevation of the immune-regulatory cytokine - TGF-P2. The differential expression of cytokines chemokines following infection with different influenza viruses could be a key determinant for clinical outcome. The potential of using these cytokines chemokines as prognostic markers or targets of therapy is worth exploring. Background Avian influenza viruses AIV are classified into two pathotypes. The highly pathogenic type HPAIV causes severe disease with a high mortality rate whereas the low pathogenic type LPAIV causes asymptomatic infection or a mild disease 1 2 . Human infection with HPAIV H5N1 was first detected in Hong Kong in 1997 3-5 . As at July 2009 more than 400 human infections have been reported to the World health Organization WHO and with an average case fatality rate of greater than 60 WHO 2010 . Hypercytokinaemia was consistently reported from patients with fatal H5N1 infection 4 6-9 . Influenza viruses of the H9 subtype have been widely circulated in the world since their first detection from turkeys in Wisconsin in 1966 10