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Báo cáo khoa học: "Pathogenesis of aerosolized Eastern Equine Encephalitis virus infection in guinea pigs"

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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Pathogenesis of aerosolized Eastern Equine Encephalitis virus infection in guinea pigs | Virology Journal BioMed Central Research Pathogenesis of aerosolized Eastern Equine Encephalitis virus infection in guinea pigs Chad J Roy 1 Douglas S Reed2 Catherine L Wilhelmsen3 Justin Hartings4 Sarah Norris3 and Keith E Steele5 Open Access Address 1Division of Microbiology Tulane National Primate Research Center Covington Louisiana USA 2Center for Vaccine Research University of Pittsburgh Pittsburgh Pennsylvania USA 3Office of the Commander United States Army Medical Research Institute of Infectious Diseases Fort Detrick Maryland USA 4Biaera Technologies LLC Frederick Maryland USA and 5Division of Pathology United States Army Medical Research Institute of Infectious Diseases Fort Detrick Maryland USA Email Chad J Roy - croy@tulane.edu Douglas S Reed - dsreed@pitt.edu Catherine LWilhelmsen - cathy.wilhelmsen@det.usamriid.army.mil Justin Hartings - jhartings@biaera.com Sarah Norris - sarah.norris@us.army.mil Keith E Steele - keith.steele1@us.army.mil Corresponding author Published 23 October 2009 Received 9 September 2009 Accepted 23 October 2009 Virology Journal 2009 6 170 doi 10.ll86 1743-422X-6-170 This article is available from http www.virologyj.com content 6 1 170 2009 Roy et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Mice and guinea pigs were experimentally exposed to aerosols containing regionally-distinct strains NJ 1959 or ArgM of eastern equine encephalitis virus EEEV at two exclusive particle size distributions. Mice were more susceptible to either strain of aerosolized EEEV than were guinea pigs however clinical signs indicating encephalitis were more readily observed in the guinea pigs. Lower lethality was observed in .

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