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Báo cáo toán học: " Development and implementation of explicit computerized protocols for mechanical ventilation in children"

Tuyển tập các báo cáo nghiên cứu khoa học ngành toán học được đăng trên tạp chí toán học quốc tế đề tài: Development and implementation of explicit computerized protocols for mechanical ventilation in children | Jouvet et al. Annals of Intensive Care 2011 1 51 http www.annalsofintensivecare.eom content 1 1 51 Ù Annals of Intensive Care a SpringerOpen Journal REVIEW Open Access Development and implementation of explicit computerized protocols for mechanical ventilation in children Philippe Jouvet1 2 Patrice Hernert2 and Marc Wysocki2 Abstract Mechanical ventilation can be perceived as a treatment with a very narrow therapeutic window i.e. highly efficient but with considerable side effects if not used properly and in a timely manner. Protocols and guidelines have been designed to make mechanical ventilation safer and protective for the lung. However variable effects and low compliance with use of written protocols have been reported repeatedly. Use of explicit computerized protocols for mechanical ventilation might very soon become a must. Several closed loop systems are already on the market and preliminary studies are showing promising results in providing patients with good quality ventilation and eventually weaning them faster from the ventilator. The present paper defines explicit computerized protocols for mechanical ventilation describes how these protocols are designed and reports the ones that are available on the market for children. Introduction Mechanical ventilation is a sophisticated technique that can keep alive the most severely ill patients however it can simultaneously damage the lungs and unfortunately generate unwanted complications 1 . By analogy with pharmacology mechanical ventilation can be viewed as a treatment with very narrow therapeutic windows i.e. highly efficient but with considerable side effects if not used properly and in a timely manner. During the past two decades considerable knowledge has been gained to find the optimal risk benefit balance for mechanical ventilation. For instance protective ventilation with low tidal volume VT and low airway pressure Paw has been shown to be safer than ventilation with high VT and Paw in adults with .