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Báo cáo toán học: " Community-acquired necrotizing pneumonia due to methicillin-sensitive Staphylococcus aureus secreting Panton-Valentine leukocidin: a review of case reports"

Tuyển tập các báo cáo nghiên cứu khoa học ngành toán học được đăng trên tạp chí toán học quốc tế đề tài: Community-acquired necrotizing pneumonia due to methicillin-sensitive Staphylococcus aureus secreting Panton-Valentine leukocidin: a review of case reports | Kreienbuehl et al. Annals of Intensive Care 2011 1 52 http www.annalsofintensivecare.eom content 1 1 52 Ù Annals of Intensive Care a SpringerOpen Journal RESEARCH Open Access Community-acquired necrotizing pneumonia due to methicillin-sensitive Staphylococcus aureus secreting Panton-Valentine leukocidin a review of case reports Lukas Kreienbuehl1 Emmanuel Charbonney2 and Philippe Eggimann3 Abstract Background Community-acquired necrotizing pneumonia caused by Panton-Valentine leukocidin PVL -secreting Staphylococcus aureus is a highly lethal infection that mainly affects healthy children and young adults. Both methicillin-sensitive S. aureus MSSA and methicillin-resistant S. aureus MRSA may carry the PVL-phage but the majority of publications relate to community-associated methicillin-resistant S. aureus CA-MRSA or mixed patient groups. This study focuses on necrotizing pneumonia due to methicillin-sensitive S. aureus strains with the purpose to determine factors associated with outcome. Methods We report a patient with PVL secreting MSSA necrotizing pneumonia and performed a systematic review of similar case in the literature. We analyzed factors associated with outcome. Results A total of 32 patient descriptions were retained for analysis. Septic shock p 0.007 influenza-like prodrome p 0.02 and the absence of a previous skin and soft-tissue infection p 0.024 were associated with fatal outcome. In multivariate analysis influenza-like prodrome odds ratio OR 7.44 95 confidence interval CI 1.24-44.76 p 0.028 and absence of previous skin and soft-tissue infection OR 0.09 95 CI 0.01-0.86 p 0.036 remained significant predictors of death. Conclusions Influenza-like prodrome may be predictive of adverse outcome in PVL-secreting MSSA necrotizing pneumonia. In contrast previous skin and soft-tissue infection may be associated with improved prognosis. Background Staphylococcus aureus is estimated to cause 1-10 of community acquired pneumonias CAP and 20-50 of nosocomial .