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Nghiên cứu nồng độ Homocysteine máu, yếu tố nguy cơ mới của tai biến mạch máu não

1.1. To affirm the mean concentration of homocysteinemia in patient-control group. 1.2. To affirm the percentage of hyperhomocysteinemia in patient-control group. 1.3. To survey the correlation between the mean concentration of homocysteinemia and some other risk factors in stroke patients. 2. Methods To quantitate the concentration of homocysteinemia in fasting (at least in 12 hours). To examine bilan lipid of the blood and to estimate some other risk factors in 108 stroke patients with stroke (mean age + 1SD, 62,4 + 13, 65 males, 43. | NGHIÊN CỨU NÔNG ĐỘ HOMOCYSTEINE MÁU YẾU TỐ NGUY CƠ MỚI CủA TAI BIẾN MẠCH MÁU NÃO TẠI TỈNH THỪA THIÊN HUÊ RESEARCH ON THE CONCENTRATION OF HOMOCYSTEINEMIA A NEW RISK FACTOR IN STROKE PATIENTS AT THUA THIEN HUE PROVINCE ThS. Nguyễn Đức Hoàng ThS. Lê Thanh Hải ThS. Lê Chuyển PGS. TS. Hoàng Khánh PGS TS. Huỳnh Đình Chiến TS. Phan Thị Danh Sở Y Tế Thừa Thiên - Huế Đại Học Y Huế Bệnh Viện Chợ Rẫy Abstract 1. Objects 1.1. To affirm the mean concentration of homocysteinemia in patient-control group. 1.2. To affirm the percentage of hyperhomocysteinemia in patient-control group. 1.3. To survey the correlation between the mean concentration of homocysteinemia and some other risk factors in stroke patients. 2. Methods To quantitate the concentration of homocysteinemia in fasting at least in 12 hours . To examine bilan lipid of the blood and to estimate some other risk factors in 108 stroke patients with stroke mean age 1SD 62 4 13 65 males 43 females and 108 healthy control subjects mean age 1SD 62 13 4 65 males 43 females with age and sex corresponding at the Hue Central Hospital 2004 . 3. Results The mean concentration of homocysteinemia in patient group 17 27 7 48 pmol L was higher than in control group 10 79 2 73 pmol L p 0 001 . The percentage of Homocysteinemia in patient group 68 52 was higher than in control group 18 52 p 0 001 . The odds ratio OR increased following quartile of healthy controls group corresponding. There were statistically significant correlations between the mean concentration of homocysteinemia and some risk factors in stroke patients. 4. Conclusions - There is hyperhomocysteinemia in stroke patients. Hyperhomocysteinemia in stroke patients are a new risk factor in the pathogenesis of stroke. - The percentage of hyperhomocysteinemia in patient group was higher than in healthy control group p 0 001 . - There were statistically significant correlations between the mean concentration of homocysteinemia and some risk factors in stroke patients. Tóm tắt