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Báo cáo Y học: Characteristics of binding of insulin-like growth factor (IGF)-I and IGF-II analogues to the type 1 IGF receptor determined by BIAcore analysis

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Insulin-like growth factor (IGF) binding to the type 1 IGF receptor (IGF1R) elicits mitogenic e ects, promotion of di erentiation and protection from apoptosis. This study has systematically measured IGF1R binding a nities of IGF-I, IGF-II and 14 IGF analogues to a recombinant high-a nity form of the IGF1R using BIAcore technology. The analogues assessed could be divided into two groups: (a) those designed to investigate binding of IGF-binding protein, which exhibited IGF1R-binding a nities similar to those of IGF-I or IGF-II;.

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