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Báo cáo y học: " No associations of Helicobacter pylori infection and gastric atrophy with plasma total homocysteine in Japanes"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: No associations of Helicobacter pylori infection and gastric atrophy with plasma total homocysteine in Japanese. | Int. J. Med. Sci. 2007 4 98 Research Paper International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2007 4 2 98-104 Ivyspring International Publisher. All rights reserved No associations of Helicobacter pylori infection and gastric atrophy with plasma total homocysteine in Japanese Simon Itou1 2 Yasuyuki Goto1 Takaaki Kondo3 Kazuko Nishio1 Sayo Kawai1 Yoshiko Ishida 1 Mariko Naito1 and Nobuyuki Hamajima1 1. Department of Preventive Medicine Biostatistics and Medical Decision Making Nagoya University Graduate School of Medicine 65 Tsurumai-cho Showa-ku Nagoya 466-8550 Japan 2. Division of Thoracic Surgery Department of Surgery Nagoya University Graduate School of Medicine 65 Tsurumai-cho Showa-ku Nagoya 466-8550 Japan 3. Department of Medical Technology Nagoya University School of Health Sciences 1-1-20 Daikominami Higashi-ku Nagoya 461-8673 Japan Correspondence to Simon Itou Department of Preventive Medicine Biostatistics and Medical Decision Making Nagoya University Graduate School of Medicine 65 Tsurumai-cho Showa-ku Nagoya 466-8550 Japan. E-mail simon@med.nagoya-u.ac.jp Phone 81-52- 744-2132 Fax 81-52-744-2971 Received 2007.01.12 Accepted 2007.03.13 Published 2007.03.14 Recent studies have suggested that Helicobacter pylori H. pylori infection might be a risk factor for atherosclerosis. Since the bacterium has not been isolated from atherosclerotic lesions a direct role in atherogenesis is not plausible. We examined associations of plasma total homocysteine tHcy and serum folate independent risk factors for atherosclerosis with H. pylori infection and subsequent gastric atrophy among 174 patients 78 males and 96 females aged 20 to 73 years who visited an H. pylori eradication clinic of Nagoya University from July 2004 to October 2005. Polymorphism genotyping was conducted for methylenetetrahydrofolate reductase MTHFR C677T and thymidylate synthase TS 28-bp tandem repeats by PCR with confronting two-pair primers and PCR respectively. H. pylori .