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Báo cáo y học: "Lack of Correlation between Severity of Clinical Symptoms, Skin Test Reactivity, and Radioallergosorbent Test Results in Venom-Allergic Patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Lack of Correlation between Severity of Clinical Symptoms, Skin Test Reactivity, and Radioallergosorbent Test Results in Venom-Allergic Patients. | Original Article Lack of Correlation between Severity of Clinical Symptoms Skin Test Reactivity and Radioallergosorbent Test Results in Venom-Allergic Patients R.J. Warrington MB BS PhD FRCP C Abstract Purpose To retrospectively examine the relation between skin test reactivity venom-specific immunoglobulin E IgE antibody levels and severity of clinical reaction in patients with insect venom allergy. Method Thirty-six patients including 15 females who presented with a history of allergic reactions to insect stings were assessed. The mean age at the time of the reactions was 33.4 15.1 years range 4-76 years and patients were evaluated 43.6 90 months range 1-300 months after the reactions. Clinical reactions were scored according to severity from 1 cutaneous manifestations only to 3 anaphylaxis with shock . These scores were compared to scores for skin test reactivity 0 to 5 indicating the log increase in sensitivity from 1 pg mLto 0.0001 pg mL and radioallergosorbent test RAST levels 0 to 4 indicating venom-specific IgE levels from undetectable to 17.5 kilounits of antigen per litre kUA L . Results No correlation was found between skin test reactivity Spearman s coefficient 0.15 p .377 or RAST level Spearman s coefficient 0.32 p .061 and the severity of reaction. Skin test and RAST scores both differed significantly from clinical severity p .05 but there was a significant correlation between skin test reactivity and RAST score p .042 . There was no correlation between skin test reactivity and time since reaction Spearman s coefficient 0.18 p .294 nor between RAST and time since reaction r 0.1353 p .438 . Elimination of patients tested more than 12 months after their reaction still produced no correlation between skin test reactivity p .681 or RAST score p .183 and the severity of the clinical reaction. Conclusion In venom-allergic patients in contrast to reported findings in cases of inhalant IgE-mediated allergy there appears to be no significant correlation .