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Báo cáo y học: "Stem cells, inflammation and allergy"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Stem cells, inflammation and allergy. | Allergy Asthma Clinical Immunology BioMed Central Review Stem cells inflammation and allergy Marie-Renee Blanchet and Kelly M McNagny Open Access Address The Biomedical Research Centre 2222 Health Sciences Mall University of British Columbia Vancouver British Columbia V6T 1Z3 Canada Email Marie-Renee Blanchet - marierenee@brc.ubc.ca Kelly M McNagny - kelly@brc.ubc.ca Corresponding author Published 7 December 2009 Received 19 October 2009 Allergy Asthma Clinical Immunology 2009 5 13 doi l0.ll86 l7l0-l 492-5-13 Accepted 7 December 2009 This article is available from http www.aacijournal.cOm content 5 l l3 2009 Blanchet and McNagny licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Recently many studies have suggested a potential role for early hematopoietic progenitor cell and hematopoietic stem cell HSC recruitment and differentiation in the development of allergy and inflammation. This is based largely on evidence that stem cells or CD34 progenitor cells are recruited to the site of inflammation in allergic diseases likely through many of the same adhesion and chemokine receptors used for stem cell homing to the bone marrow PSGL-l CXCLl2 alpha4-betal integrin CD44 etc . Once at the site of inflammation it has been suggested that stem cells could participate in the perpetuation of inflammation by maturing locally into inflammatory cells in response to the growth factors released in situ. Here we provide a brief review of the evidence to suggest that hematopoietic stem and progenitor cells versus mature hematopoietic lineages are indeed recruited to the site of allergic inflammation. We also discuss the molecules that likely play a role in this process and highlight a number of our novel observations on a specific role