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Báo cáo y học: "Decreased response to IL-12 and IL-18 of peripheral blood cells in rheumatoid arthritis"

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Decreased response to IL-12 and IL-18 of peripheral blood cells in rheumatoid arthritis. | Available online http arthritis-research.eom content 6 1 R39 Research article Open Access Decreased response to IL-12 and IL-18 of peripheral blood cells in rheumatoid arthritis Masanori Kawashima and Pierre Miossec Department of Immunology and Rheumatology and INSERM U-403 Pavilion F Hospital Edouard Herriot 69437 Lyon Cedex 03 France Correspondence Pierre Miossec pierre.miossec@univ-lyon1.fr Received 8 May 2003 Revisions requested 11 Jun 2003 Revisions received 29 Sep 2003 Accepted 13 Oct 2003 Published 4 Nov 2003 Arthritis Res Ther 2004 6 R39-R45 DOI 10.1186 ar1020 2004 Kawashima and Miossec licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Inflamed synovium of rheumatoid arthritis RA has been associated with a T helper Th 1 cytokine profile but the blood situation remains to be clarified. We studied the differential IFN-y producing activity of peripheral blood mononuclear cells PBMCs from RA patients RA-PBMCs and from healthy controls H-PBMCs in response to IL-12 and IL-18. RA-PBMCs had a decreased IFN-y production in response to IL-12 and IL-18 when compared with H-PBMCs. RA-PBMCs activated with phytohemagglutinin and phorbol 12-myristate 13-acetate showed an increased sensitivity to IL-12 and IL-18 but still the RA-PBMC response was lower. IL-18 increased IL-1 2-stimulated IFN-y production from RA synovium cells obtained after collagenase digestion more effectively than that of RA- or H-PBMCs. A specific inhibitor of IL-18 bioactivity IL-18-binding protein IL-18BP down-regulated IL-12-induced IFN-y production by RA- or H-PBMCs and had a remarkable effect on RA synovium cells. In conclusion RA disease combines a polarized immune response with an active Th1 in inflamed joints and a reduced Th1 pattern in peripheral circulation. .

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