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báo cáo khoa học: "Down-regulation of TM4SF is associated with the metastatic potential of gastric carcinoma TM4SF members in gastric carcinoma"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Down-regulation of TM4SF is associated with the metastatic potential of gastric carcinoma TM4SF members in gastric carcinoma | Chen et al. World Journal of Surgical Oncology 2011 9 43 http www.wjso.eom content 9 1 43 5 2 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Down-regulation of TM4SF is associated with the metastatic potential of gastric carcinoma TM4SF members in gastric carcinoma 1.2 2 2 11 2 Zhouxun Chen 1 Suchen Gu Bogusz Trojanowicz Naxin Liu Guanbao Zhu Henning Dralle and Cuong Hoang-Vu2 Abstract Background The aim of this study was to clarify the clinical significance of TM4SF members CD9 CD63 and CD82 in human gastric carcinoma. Methods By employing RT-PCR and immunohistochemistry we studied the expression of CD9 CD63 and CD82 in 49 paired tissue specimens of normal gastric mucosa and carcinoma. All tissues were obtained from patients who underwent curative surgery. Results All normal gastric epithelium and gastric ulcer tissues strongly expressed transcripts and proteins of CD9 CD63 and CD82 as compared with corresponding controls. We found a significant correlation between CD63 mRNA level and different pM statuses P 0.036 . Carcinomas in M0 stage revealed a stronger expression of CD63 than carcinomas in M1 stage. Expression of CD9 protein was found significantly stronger in pN0 pM0 than in advanced pN stages P 0.03 pM1 P 0.013 respectively. We found the relationship between CD63 expression gender p 0.09 and nodal status p 0.028 respectively. Additionally advanced and metastasized tumor tissues revealed significantly down-regulated CD82 protein expression p 0.033 and p 0 respectively which correlated with the tumor pTNM stage p 0.001 . Conclusion The reduction of CD9 CD63 and CD82 expression are indicators for the metastatic potential of gastric carcinoma cells. Unlike their expression in other tumor types the constitutive expression of CD63 may indicate that this factor does play a direct role in human gastric carcinogenesis. Introduction The TM4 superfamily TM4SF includes more than 20 core members and a number of additional proteins with sequence similarities. .