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Báo cáo khoa học: "The efficacy of preoperative PET/CT for prediction of curability in surgery for locally advanced gastric carcinoma"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The efficacy of preoperative PET/CT for prediction of curability in surgery for locally advanced gastric carcinoma | Hur et al. World Journal of Surgical Oncology 2010 8 86 http www.wjso.eom content 8 1 86 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access The efficacy of preoperative PET CT for prediction of curability in surgery for locally advanced gastric carcinoma 1 2 3 3 3 3 Hoon Hur Sung Hoon Kim Wook Kim Kyo Young Song Cho Hyun Park Hae Myung Jeon Abstract Background The benefits of preoperative 18FDG-PET CT for gastric cancer remain uncertain. The aim of this study was to investigate the effects of preoperative 18FDG-PET CT on the surgical strategy for locally advanced gastric cancer retrospectively. Methods From January 2007 to November 2008 18FDG-PET CT was performed in 142 patients who had been diagnosed with advanced gastric cancer by computed tomography or gastrofiberscope findings. Results Detection rates were 88.7 126 142 for primary tumors and 24.6 35 142 for local lymph nodes LN . Nine patients with metastatic lesions underwent induction chemotherapy without operation. Of 133 patients subjected to operation positive FDG uptake in primary tumors p 0.047 and local lymph nodes p 0.001 was related to non-curable operations. The mean standard uptake value SUV of primary tumors of patients who underwent non-curable operations was significantly higher than that of patients with curable operations p 0.001 . When the SUV was greater than 5 and FDG uptake of LN was positive non-curable operations were predicted with a sensitivity of 35.2 a specificity of 91.0 and an accuracy of 76.7 . Conclusions High SUV of the primary tumor and positive FDG uptake in local lymph nodes at PET CT could predict non-curative resection in locally advanced gastric cancer. Therefore information from preoperative PET CT can help physician decisions regarding other modalities without laparotomy. Background Preoperative imaging studies are used to evaluate clinical and surgical factors of malignant tumors including resectability and identification of metastatic lesions that contraindicate .