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Báo cáo y học: "Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis. | Available online http arthritis-research.eom content 7 5 R949 Research article Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis Annette HM van der Helm-van Mil Kirsten N Verpoort Ferdinand C Breedveld René EM Toes and Tom WJ Huizinga Department of Rheumatology Leiden University Medical Center Leiden The Netherlands Corresponding author Annette HM van der Helm-van Mil Avdhelm@lumc.nl Received 23 Mar 2005 Revisions requested 18 Apr 2005 Revisions received 22 Apr 2005 Accepted 11 May 2005 Published 14 Jun 2005 Arthritis Research Therapy 2005 7 R949-R958 DOI 10.11 86 ar1 767 This article is online at http arthritis-research.com content 7 5 R949 2005 van der Helm-van Mil et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Open Access Abstract Antibodies to citrullinated proteins anti-eyelie-eitrullinated peptide anti-CCP antibodies are highly specific for rheumatoid arthritis RA and precede the onset of disease symptoms indicating a pathogenetic role for these antibodies in RA. We recently showed that distinct genetic risk factors are associated with either anti-CCP-positive disease or anti-CCP-negative disease. These data are important as they indicate that distinct pathogenic mechanisms are underlying anti-CCP-positive disease or anti-CCP-negative disease. Likewise these observations raise the question of whether anti-CCP-positive RA and anti-CCP-negative RA are clinically different disease entities. We therefore investigated whether RA patients with anti-CCP antibodies have a different clinical presentation and disease course compared with patients without these autoantibodies. In a cohort of 454 incident patients with RA 228 patients were anti-CCP-positive and 226 patients were .