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Báo cáo y học: "Rheumatoid arthritis is an independent risk factor for multi-vessel coronary artery disease: a case control study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Rheumatoid arthritis is an independent risk factor for multi-vessel coronary artery disease: a case control study. | Available online http arthritis-research.eom content 7 5 R984 Research article Rheumatoid arthritis is an independent risk factor for multi-vessel coronary artery disease a case control study Kenneth J Warrington1 Peter D Kent1 Robert L Frye2 James F Lymp4 Stephen L Kopecky2 3 Jorg J Goronzy1 5 and Cornelia M Weyand1 5 1Division of Rheumatology Mayo Clinic Rochester MN USA 2Division of Cardiovascular Diseases Mayo Clinic Rochester MN USA 3Mayo Alliance for Clinical Trials and the Mayo Clinic Rochester MN USA 4Division of Biostatistics Mayo Clinic Rochester MN USA 5Emory University School of Medicine Atlanta GA USA Corresponding author Kenneth J Warrington kwarring@utmem.edu Received 29 Dec 2004 Revisions requested 27 Jan 2005 Revisions received 23 May 2005 Accepted 25 May 2005 Published 29 Jun 2005 Arthritis Research Therapy 2005 7 R984-R991 DOI 10.11 86 ar1 775 This article is online at http arthritis-research.com content 7 5 R984 2005 Warrington et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract The risk for cardiovascular CV disease is increased in rheumatoid arthritis RA but data on the burden of coronary atherosclerosis in patients with RA are lacking. We conducted a retrospective case-control study of Olmsted County MN USA residents with RA and new-onset coronary artery disease CAD n 75 in comparison with age-and sex-matched controls with newly diagnosed CAD n 1 28 . Angiographic scores of the first coronary angiogram and data on CV risk factors and CV events on follow-up were obtained by chart abstraction. Patients with RA were more likely to have multivessel coronary involvement at first coronary angiogram compared with controls P 0.002 . Risk factors for CAD including diabetes hypertension