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Báo cáo y học: "Association between the TNFRII 196R allele and diagnosis of rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Association between the TNFRII 196R allele and diagnosis of rheumatoid arthritis. | Available online http arthritis-research.eom content 7 5 R1056 Research article Association between the TNFRII 196R allele and diagnosis of rheumatoid arthritis Vincent Goeb1 2 Philippe Dieudé3 Olivier Vittecoq1 2 Othmane Mejjad1 Jean-Franọois Ménard4 Marlène Thomas2 Danièle Gilbert2 Patrick Boumier5 Sophie Pouplin1 Alain Daragon1 2 Patrice Fardellone5 Franọois Tron2 Franọois Cornélis3 and Xavier Le Loet1 2 Open Access Rheumatology Department University Hospital of Rouen Rouen France 2Inserm U519 IFRMP 23 Faculty of Medicine Rouen France 3GenHotel University of Evry-Paris VII Faculty of Lariboisière-Saint Louis Evry-Genopole and Unité de Génétique clinique University Hospital of Lariboisière APHP Paris France 4Biostatistics Department University Hospital of Rouen Rouen France 5Rheumatology Department University Hospital of Amiens Amiens France Contributed equally Corresponding author Vincent Goeb goebvince@yahoo.fr Received 6 Feb 2005 Revisions requested 1 6 Feb 2005 Revisions received 1 0 May 2005 Accepted 31 May 2005 Published 29 June 2005 Arthritis Research Therapy 2005 7 R1056-R1062 This article is online at http arthritis-research.com content 7 5 R1056 2005 Goeb et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Tumour necrosis factor TNF -a plays a key role in the pathogenesis of rheumatoid arthritis RA . It binds to two receptors namely TNF receptor TNFR I and TNFRII. Several studies have suggested an association between TNFRII 196R R genotype and RA. The objective of the present study was to evaluate the predictive value of the TNFRII 196R allele for RA diagnosis and prognosis in a cohort of patients with very early arthritis. We followed up a total of 278 patients recruited from the community who had .