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Báo cáo y học: "Differential direct effects of cyclo-oxygenase-1/2 inhibition on proteoglycan turnover of human osteoarthritic cartilage: an in vitro study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Differential direct effects of cyclo-oxygenase-1/2 inhibition on proteoglycan turnover of human osteoarthritic cartilage: an in vitro study. | Available online http arthritis-research.eom content 8 1 R2 Research article Differential direct effects of cyclo-oxygenase-1 2 inhibition on proteoglycan turnover of human osteoarthritic cartilage an in vitro study Simon C Mastbergen Nathalie WD Jansen Johannes WJ Bijlsma and Floris PJG Lafeber Rheumatology Clinical Immunology University Medical Center Utrecht Utrecht The Netherlands Corresponding author Simon C Mastbergen s.mastbergen@azu.nl Received 7 Jul 2005 Revisions requested 2 Aug 2005 Revisions received 29 Sep 2005 Accepted 10 Oct 2005 Published 9 Nov 2005 Arthritis Research Therapy 2006 8 R2 doi 10.1186 ar1846 This article is online at http arthritis-research.com content 8 1 R2 2005 Mastbergen et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Treatment of osteoarthritis OA with nonsteroidal antiinflammatory drugs NSAIDs diminishes inflammation along with mediators of cartilage destruction. However NSAIDs may exert adverse direct effects on cartilage particularly if treatment is prolonged. We therefore compared the direct effects of indomethacin naproxen aceclofenac and celecoxib on matrix turnover in human OA cartilage tissue. Human clinically defined OA cartilage from five different donors was exposed for 7 days in culture to indomethacin naproxen aceclofenac and celecoxib - agents chosen based on their cyclo-oxygenase COX -2 selectivity. As a control SC-560 a selective COX-1 inhibitor was used. Changes in cartilage proteoglycan turnover and prostaglandin E2 production were determined. OA cartilage exhibited characteristic proteoglycan turnover. Indomethacin further inhibited proteoglycan synthesis no significant effect of indomethacin on proteoglycan release was found and proteoglycan .