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Báo cáo y học: "Lack of association between mannose-binding lectin gene polymorphisms and juvenile idiopathic arthritis in a Han population from the Hubei province of China"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Lack of association between mannose-binding lectin gene polymorphisms and juvenile idiopathic arthritis in a Han population from the Hubei province of China. | Available online http arthritis-research.eom content 8 4 R85 Research article Lack of association between mannose-binding lectin gene polymorphisms and juvenile idiopathic arthritis in a Han population from the Hubei province of China Min Kang1 Hong-Wei Wang1 Pei-Xuan Cheng1 Zun-Dong Yin2 Xiao-Ou Li1 Hong Shi1 and Xiu-Fen Hu1 Department of Pediatrics Tongji Hospital Tongji Medical College Hua Zhong University of Science and Technology 1095 Jie Fang Avenue Wuhan 430030 Hubei Province China 2Chinese Center for Disease Control and Prevention 27 Nan Wei Road Beijing 100050 China Corresponding author Hong-Wei Wang hwwang@tjh.tjmu.edu.cn Received 1 Jan 2006 Revisions requested 8 Feb 2006 Revisions received 2 Mar 2006 Accepted 9 Apr 2006 Published 8 May 2006 Arthritis Research Therapy 2006 8 R85 doi 10.1186 ar1 953 This article is online at http arthritis-research.com content 8 4 R85 2006 Kang et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Many studies have reported that polymorphisms of the mannose-binding lectin MBL gene are associated with autoimmune disease. Here we investigate the relationship between MBL gene polymorphisms and susceptibility to juvenile idiopathic arthritis JIA in a Han-nationality population from the Hubei province of China. PCR-restriction fragment length polymorphism was used to investigate polymorphisms of codons 54 and 57 in exon 1 of the MBL gene in 93 patients with JIA and 48 control children. Neither group showed codon 57 polymorphisms. There was no significant difference in the genotypic frequencies of codon 54 between patients with JIA and healthy controls wild type 71.0 versus 75.0 respectively heterozygous type 25.8 versus 25.0 respectively and homozygous type 3.2 .