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Báo cáo y học: "Characteristics of repair tissue in second-look and third-look biopsies from patients treated with engineered cartilage: relationship to symptomatology and time after implantation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Characteristics of repair tissue in second-look and third-look biopsies from patients treated with engineered cartilage: relationship to symptomatology and time after implantation. | Available online http arthritis-research.eom content 10 6 R132 Research article Characteristics of repair tissue in second-look and third-look biopsies from patients treated with engineered cartilage relationship to symptomatology and time after implantation Paola Brun1 Sally C Dickinson2 Barbara Zavan1 Roberta Cortivo1 Anthony P Hollander2 and Giovanni Abatangelo1 Department of Histology Microbiology and Medical Biotechnology Histology Unit Faculty of Medicine University of Padova Viale G. Colombo 3 35121 Padova Italy 2Department of Cellular Molecular Medicine University of Bristol School of Medicine Sciences University Walk Bristol BS8 1TD UK Corresponding author Paola Brun paola.brun@unipd.it Received 9 Jun 2008 Revisions requested 24 Jul 2008 Revisions received 15 Oct 2008 Accepted 11 Nov 2008 Published 11 Nov 2008 Arthritis Research Therapy 2008 10 R132 doi 10.11 86 ar2549 This article is online at http arthritis-research.com content 10 6 R132 2008 Brun et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The present study established characteristics of tissue regrowth in patients suffering knee lesions treated with grafts of autologous chondrocytes grown on three-dimensional hyaluronic acid biomaterials. Methods This multicentred study involved a second-look arthroscopy biopsy 5 to 33 months post implant n 63 . Seven patients allowed a third-look biopsy three of which were performed 18 months post implant. Characteristics of tissues were histologically and histochemically evaluated. The remaining bone stubs were evaluated for cartilage bone integration. For data analysis biopsies were further divided into those obtained from postoperative symptomatic patients n 41 or from .