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Báo cáo y học: "Markers of B-lymphocyte activation are elevated in patients with early rheumatoid arthritis and correlated with disease activity in the ESPOIR cohort"

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Markers of B-lymphocyte activation are elevated in patients with early rheumatoid arthritis and correlated with disease activity in the ESPOIR cohort. | Available online http arthritis-research.eom content 11 4 R114 Open Access Research article Markers of B-lymphocyte activation are elevated in patients with early rheumatoid arthritis and correlated with disease activity in the EsPOIR cohort Jacques-Eric Gottenberg1 Corinne Miceli-Richard1 Beatrice Ducot2 Philippe Goupille3 Bernard Combe4 and Xavier Mariette5 1Rhumatologie Hôpitaux Universitaires de Strasbourg Centre de Reference National des Maladies Auto-Immunes Systémique Rares EA 3432 Physiopathologie des Arthrites Strasbourg France 2Institut Pour la Santé et la Recherche Médicale INSERM Unite 822 Epidémiologie Démographie et Sciences Sociales IFR69 Institut National d Etudes Démographiques INED Université Paris 11 Le Kremlin-Bicêtre France 3CHRU de Tours UMR CNRS 6239 Université de Tours INSERM CIC-202 Tours France 4Immuno-Rhumatologie Hôpital Lapeyronie Université Montpellier 1 UGM 5535 Montpellier France 5Rhumatologie INSERM U802 Université Paris-Sud 11 Hôpital Bicêtre Assistance Publique-Hôpitaux de Paris AP-HP Le Kremlin Bicêtre France Corresponding author Xavier Mariette xavier.mariette@bct.ap-hop-paris.fr Received 23 Feb 2009 Revisions requested 18 Mar 2009 Revisions received 3 Jun 2009 Accepted 23 Jul 2009 Published 23 Jul 2009 Arthritis Research Therapy 2009 11 R114 doi 10.11 86 ar2773 This article is online at http arthritis-research.com content 11 4 R114 2009 Gottenberg et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Little is known about systemic B-cell activation in early rheumatoid arthritis RA . We therefore evaluated the serum levels of markers of B-cell activation in patients included in the ESPOIR early arthritis cohort. Methods In the ESPOIR early arthritis cohort at least

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