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Báo cáo y học: "Association between IL-18 gene polymorphisms and biopsy-proven giant cell arteritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Association between IL-18 gene polymorphisms and biopsy-proven giant cell arteritis. | Palomino-Morales et al. Arthritis Research Therapy 2010 12 R51 http arthritis-research.eom content 12 2 R51 RESEARCH ARTICLE Open Access Association between IL-18 gene polymorphisms and biopsy-proven giant cell arteritis Rogelio J Palomino-Morales1 Tomas R Vazquez-Rodriguez2 Orlando Torres1 Inmaculada C Morado3 c s Z S. r- s r- s -J 4 I z s. f- I . h I J Z L . D I I I z- I2 I z f- z- I I I z- I z- Di 11 I Z S5 D I KỲ I c rr-. I 7 CLi itinrm 3 Santos Castaneda Jose A Miranda-rilloy Jose L Callejas-Rubio Benjamin rernandez-Gutierrez Miguel A Gonzalez-Gay63 Javier Martin1 3 Abstract Introduction The objective was to investigate the potential implication of the IL18 gene promoter polymorphisms in the susceptibility to giant-cell arteritis GCA . Methods In total 212 patients diagnosed with biopsy-proven GCA were included in this study. DNA from patients and matched controls was obtained from peripheral blood. Samples were genotyped for the IL18-137 G C rs187238 the IL18-607 C A rs1946518 and the IL18-1297 T C rs360719 gene polymorphisms with polymerase chain reaction by using a predesigned TaqMan allele discrimination assay. Results No significant association between the IL18-137 G C polymorphism and GCA was found. However the IL18 -607 allele A was significantly increased in GCA patients compared with controls 47.8 versus 40.9 in patients and controls respectively P 0.02 OR 1.32 95 CI 1.04 to 1.69 . It was due to an increased frequency of homozygosity for the IL 18 -607 A A genotype in patients with GCA 20.4 compared with controls 13.4 IL18 -607 A A versus IL18 -607 A C plus IL18 -607 C C genotypes P 0.04 OR 1.59 95 CI 1.02 to 2.46 . Also the IL18-1297 allele C was significantly increased in GCA patients 30.7 compared with controls 23.0 P 0.003 OR 1.48 95 CI 1.13 to 1.95 . In this regard an increased susceptibility to GCA was observed in individuals carrying the IL18-1297 C C or the IL18-1297 C T genotypes compared with those carrying the IL18-1297 T T genotype .