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Báo cáo y học: " Nitric oxide gas phase release in human small airway epithelial cells"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Nitric oxide gas phase release in human small airway epithelial cells. | Respiratory Research BioMed Central Research Nitric oxide gas phase release in human small airway epithelial cells Jingjing Jiang1 Nikita Malavia2 Vinod Suresh1 and Steven C George 1 2 Open Access Address Department of Biomedical Engineering University of California Irvine Irvine CA USA and 2Department of Chemical Engineering and Material Science University of California Irvine Irvine USA Email Jingjing Jiang - jingjinj@uci.edu Nikita Malavia - nmalavia@uci.edu Vinod Suresh - vinod.suresh@gmail.com Steven C George - scgeorge@uci.edu Corresponding author Published 19 January 2009 Received 6 August 2008 Respiratory Research 2009 10 3 doi l0.ll86 l465-992l-l0-3 Accepted 19 January 2009 This article is available from http respiratory-research.cOm content l0 l 3 2009 Jiang et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Asthma is a chronic airway inflammatory disease characterized by an imbalance in both Thl and Th2 cytokines. Exhaled nitric oxide NO is elevated in asthma and is a potentially useful non-invasive marker of airway inflammation. However the origin and underlying mechanisms of intersubject variability of exhaled NO are not yet fully understood. We have previously described NO gas phase release from normal human bronchial epithelial cells NHBEs tracheal origin . However smaller airways are the major site of morbidity in asthma. We hypothesized that IL-13 or cytomix IL-lp TNF-a and IFN-y stimulation of differentiated small airway epithelial cells SAECs generation l0 l2 and A549 cells model cell line of alveolar type II cells in culture would enhance NO gas phase release. Methods Confluent monolayers of SAECs and A549 cells were cultured in Transwell plates and SAECs were allowed to .